发明授权
US08980855B2 Minor groove binder (MGB)-oligonucleotide miRNA antagonists
有权
次要沟槽粘合剂（MGB） - 寡核苷酸miRNA拮抗剂
- 专利标题： Minor groove binder (MGB)-oligonucleotide miRNA antagonists
- 专利标题（中）： 次要沟槽粘合剂（MGB） - 寡核苷酸miRNA拮抗剂
-
申请号： US13490634申请日： 2012-06-07
-
公开(公告)号： US08980855B2公开(公告)日： 2015-03-17
- 发明人: Anastasia Khvorova , Annaleen Vermeulen , Rob Kaiser , Jon Karpilow , Nicolaas M. J. Vermeulen , Walt Mahoney
- 申请人： Anastasia Khvorova , Annaleen Vermeulen , Rob Kaiser , Jon Karpilow , Nicolaas M. J. Vermeulen , Walt Mahoney
- 申请人地址： NL Spankeren US CO Lafayette
- 专利权人： Elitech Holding B.V.,GE Healthcare Dharmacon, Inc.
- 当前专利权人： Elitech Holding B.V.,GE Healthcare Dharmacon, Inc.
- 当前专利权人地址： NL Spankeren US CO Lafayette
- 代理机构： Jackson Walker L.L.P.
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C12Q1/68 ; C07H21/04
摘要：
Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.