发明授权
- 专利标题： Transgenic non-human animal and uses thereof
- 专利标题（中）： 转基因非人动物及其用途
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申请号： US13516077申请日： 2010-12-17
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公开(公告)号： US08981179B2公开(公告)日： 2015-03-17
- 发明人: Holly Dressler , Kyriakos D. Economides , Zhen Pang , Harry Gregory Polites
- 申请人： Holly Dressler , Kyriakos D. Economides , Zhen Pang , Harry Gregory Polites
- 申请人地址： US NJ Bridgewater
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： US NJ Bridgewater
- 代理机构： Lathrop & Gage LLP
- 代理商 James H. Velema, Esq.
- 优先权： FR1057663 20100923
- 国际申请： PCT/US2010/060909 WO 20101217
- 国际公布： WO2011/084659 WO 20110714
- 主分类号： A01K67/00
- IPC分类号： A01K67/00 ; G01N33/74 ; A01K67/027 ; C12N9/02 ; C12N15/85
摘要：
The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway modulation following ligand binding of GPCR receptors.
公开/授权文献
- US20120255041A1 TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF 公开/授权日：2012-10-04
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