Methods and systems for dynamically detecting and switching profiling configuration in digital rendering. A set of color patches utilized for profiling can be rendered via a calibration engine and the color patches can be measured via inline/offline spectrophotometer. A high-accuracy MFD model can be built based on measurement from the color patches. A set of measurement values for a set of CMYK color probes can be obtained directly from the measurement and/or by processing through a MFD model. A classifier can be configured to determine a toner set based on the predicted and/or measured Lab values. The profiling procedure then automatically sets up a parameter set for the corresponding toner set to build a color look-up table via an inversion and optimization function. A destination ICC profile can be built based on the color LUTs. The system can handle multiple toner sets and produce optimized color outcome for each toner set.