A seal assembly for sealing a space between a shaft and a housing includes a seal having a central axis, an inner annular sealing lip sealingly engageable with the shaft and an outer annular rim with an outer circumferential surfaces engageable with the housing inner surface. At least one and preferably two support members are disposed within the annular rim and at least one and preferably a plurality of adjustment devices are coupled with the support members. Each adjustment device is configured to displace at least a portion of each support member radially outwardly with respect to the central axis, to displace at least a portion of the rim generally toward the housing inner surface, and/or to displace at least a portion of each support member radially inwardly toward the central axis to permit displacement of at least a portion of the rim generally away from the housing inner surface.