Invention Grant
- Patent Title: Potent and selective mediators of cholesterol efflux
- Patent Title (中): 胆固醇流出的有效和选择性介质
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Application No.: US12519116Application Date: 2007-12-13
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Publication No.: US08987192B2Publication Date: 2015-03-24
- Inventor: John K. Bielicki , Jan Johansson
- Applicant: John K. Bielicki , Jan Johansson
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2007/087477 WO 20071213
- International Announcement: WO2008/115303 WO 20080925
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/16 ; A61K45/00 ; A61K47/24 ; A61K49/00 ; A61K51/00 ; A61K9/127 ; C07K14/00 ; C07K14/47 ; C07K14/705 ; A61P3/06 ; A61P9/00 ; C07K14/775
Abstract:
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
Public/Granted literature
- US20120329703A1 Potent and Selective Mediators of Cholesterol Efflux Public/Granted day:2012-12-27
Information query
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