发明授权
- 专利标题: Macrocycles that increase p53 activity and the uses thereof
- 专利标题(中): 增加p53活性的大环化合物及其用途
-
申请号: US14354303申请日: 2012-10-23
-
公开(公告)号: US08987274B2公开(公告)日: 2015-03-24
- 发明人: Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
- 申请人: Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp
- 当前专利权人: Merck Sharp & Dohme Corp
- 当前专利权人地址: US NJ Rahway
- 代理商 Yong Zhao; Laura M. Ginkel
- 国际申请: PCT/US2012/061403 WO 20121023
- 国际公布: WO2013/062923 WO 20130502
- 主分类号: A61K31/497
- IPC分类号: A61K31/497 ; C07D498/14 ; C07D409/14
摘要:
The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.