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公开(公告)号：US20140315916A1
公开(公告)日：2014-10-23
申请号：US14354303
申请日：2012-10-23
申请人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
发明人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
IPC分类号： C07D498/14
CPC分类号： C07D498/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供式（1）的化合物：如本文所述或其药学上可接受的盐或溶剂化物。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US08859776B2
公开(公告)日：2014-10-14
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
IPC分类号： C07D401/00 , A01N43/40 , C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式1的化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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3.发明申请公开(公告)号：US20120208844A1
公开(公告)日：2012-08-16
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Cynthia Seidel-Dugan , Gerald W. Shipps, JR. , Malcolm MacCoss
IPC分类号： A61K31/4545 , A61P35/02 , A61P35/00 , C07D409/14 , C07D401/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译： 本发明提供本文所述的式（1）化合物或其药学上可接受的盐，溶剂合物或酯。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。
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4.发明授权Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效具有环状P4的酮酰胺作为丙型肝炎病毒的NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US07619094B2
公开(公告)日：2009-11-17
申请号：US11602174
申请日：2006-11-20
申请人： Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人： Kevin X Chen , F George Njoroge , Mousumi Sannigrahi , Latha G Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号： C07D209/02 , C07D403/12 , A61K31/403
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US07244721B2
公开(公告)日：2007-07-17
申请号：US10052386
申请日：2002-01-18
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse K. Wong , Latha G. Nair
IPC分类号： A61K31/497 , A61K31/407 , A61K31/454 , A61K31/4025
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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6.发明授权Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权具有环状P4'S的酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号：US07173057B2
公开(公告)日：2007-02-06
申请号：US11065647
申请日：2005-02-24
申请人： Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
发明人： Kevin X. Chen , F. George Njoroge , Mousumi Sannigrahi , Latha G. Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane L. Bogen , Frank Bennett , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/4035 , A61K31/403 , A61K31/407 , A61K31/454 , A61K31/5355 , A61K31/4725 , A61K31/4166 , C07D209/48 , C07D209/52 , C07D209/02 , C07D471/02 , C07D401/12 , C07D413/12 , C07D217/24 , C07D233/02 , C07D233/74
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US08987274B2
公开(公告)日：2015-03-24
申请号：US14354303
申请日：2012-10-23
申请人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
发明人： Latha G. Nair , Stephane L. Bogen , Ronald J. Doll , Yao Ma , Yuan Tian
IPC分类号： A61K31/497 , C07D498/14 , C07D409/14
CPC分类号： C07D498/14 , C07D409/14
摘要： The present invention provides a compound of Formula (1): as described herein or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
摘要翻译： 本发明提供式（1）的化合物：如本文所述或其药学上可接受的盐或溶剂化物。 该化合物可用作HDM2蛋白的抑制剂。 还公开了包含上述化合物的药物组合物和使用其治疗癌症的潜在方法。
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公开(公告)号：US07423058B2
公开(公告)日：2008-09-09
申请号：US11645181
申请日：2006-12-21
申请人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
发明人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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9.发明授权Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease 有权硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US08067379B2
公开(公告)日：2011-11-29
申请号：US11064673
申请日：2005-02-24
申请人： Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
发明人： Frank Bennett , Raymond G. Lovey , Yuhua Huang , Siska Hendrata , Anil K. Saksena , Stephane L. Bogen , Yi-Tsung Liu , F. George Njoroge , Srikanth Venkatraman , Kevin X. Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor M. Girijavallabhan , Francisco Velazquez , Latha G. Nair
IPC分类号： A61K38/06
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US07718691B2
公开(公告)日：2010-05-18
申请号：US11542228
申请日：2006-10-03
申请人： Srikanth Venkatraman , F. George Njoroge , Melissa L. Blackman , Wanil Wu , Latha G. Nair , Ashok Arasappan , Stephane L. Bogen , Kevin X. Chen , Mousumi Sannigrahi , Frank Bennett , Viyyor M. Girijavallabhan
发明人： Srikanth Venkatraman , F. George Njoroge , Melissa L. Blackman , Wanil Wu , Latha G. Nair , Ashok Arasappan , Stephane L. Bogen , Kevin X. Chen , Mousumi Sannigrahi , Frank Bennett , Viyyor M. Girijavallabhan
IPC分类号： A61K31/403 , C07D209/02 , C07D403/12
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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