A method and an apparatus for uplink power control in a wireless communication system are provided. More specially, a method is provided in which a first base station in a wireless communication system periodically measures interference for a cell of a second base station neighboring the first base station, determines an average of the periodically measured interference, broadcasts the determined average of the periodically measured interference to mobile terminals located in a cell of the first base station, determines a weight for the determined average of the periodically measured interference, based on one of resource allocation information for the cell of the second base station and whether a specific message for interference regulation is received from the second base station, and transmits the determined weight to the mobile terminals.