发明授权
- 专利标题： Peptides for targeting apoptotic cells and uses thereof
- 专利标题（中）： 用于靶向凋亡细胞的肽及其用途
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申请号： US13467689申请日： 2012-05-09
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公开(公告)号： US08993721B2公开(公告)日： 2015-03-31
- 发明人: Byung Heon Lee , In San Kim
- 申请人： Byung Heon Lee , In San Kim
- 专利权人： Kyungpook National University Industry-Academic Cooperation Foundation
- 当前专利权人： Kyungpook National University Industry-Academic Cooperation Foundation
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- 代理商 Kongsik Kim; Richard B. Emmons
- 优先权： KR10-2008-0044410 20080514
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; A61K38/08 ; A61K47/48 ; A61K49/00 ; A61K38/00
摘要：
Described herein is an isolated polypeptide which is capable of specifically targeting apoptotic cells undergoing apoptosis and consists of the sequence (I): Cys-X1-Val-Ala-Pro-X2 (I), wherein X1 is an amino acid with polar uncharged side chain and X2 is an amino acid with positive charged side chain. The isolated polypeptide of the present invention may be useful for detecting apoptotic cells, as well as detecting and imaging apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue, and arteriosclerosis site; the polypeptide is useful for targeted drug delivery thereto.
公开/授权文献
- US20120316101A1 PEPTIDES FOR TARGETING APOPTOTIC CELLS AND USES THEREOF 公开/授权日：2012-12-13