发明授权
- 专利标题： Method of preparing tetrabenazine and dihydrotetrabenazine
- 专利标题（中）： 制备丁苯那嗪和二氢丁苯那嗪的方法
-
申请号： US13617357申请日： 2012-09-14
-
公开(公告)号： US08993766B2公开(公告)日： 2015-03-31
- 发明人: Sun Joon Min , Yong Seo Cho , Jae Kyun Lee , Ae Nim Pae , Young Wook Son
- 申请人： Sun Joon Min , Yong Seo Cho , Jae Kyun Lee , Ae Nim Pae , Young Wook Son
- 申请人地址： KR Seoul
- 专利权人： Korea Institute of Science and Technology
- 当前专利权人： Korea Institute of Science and Technology
- 当前专利权人地址： KR Seoul
- 代理机构： Goldilocks ZONE IP LAW
- 优先权： KR10-2012-0009756 20120131
- 主分类号： C07D455/06
- IPC分类号： C07D455/06 ; C07F7/08
摘要：
The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant and an oxidation reaction.
公开/授权文献
信息查询
