发明授权
- 专利标题： Vector comprising multiple homologous nucleotide sequences
- 专利标题（中）： 包含多个同源核苷酸序列的载体
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申请号： US13123605申请日： 2009-11-20
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公开(公告)号： US08999637B2公开(公告)日： 2015-04-07
- 发明人: Robin Steigerwald
- 申请人： Robin Steigerwald
- 申请人地址： DK Kvistgaard
- 专利权人： Bavarian Nordic A/S
- 当前专利权人： Bavarian Nordic A/S
- 当前专利权人地址： DK Kvistgaard
- 代理机构： Law Office of Salvatore Arrigo and Scott Lee, LLP
- 国际申请： PCT/EP2009/008275 WO 20091120
- 国际公布： WO2010/057650 WO 20100527
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/00 ; A61K39/12 ; A61K39/155 ; C12N15/86
摘要：
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases.
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