Systems and methods for flow control within a Serial Peripheral Interface without additional signal lines are included herein. In one example, a method includes generating a flow control command. The method also includes sending the flow control command from a master device to a slave device with a Serial Peripheral Interface. In addition, the method includes sending a memory address from the master device to the slave device. Furthermore, the method includes detecting a ready indicator in the master device. The method also includes waiting to receive a ready indicator and communicating with the slave device in response to the ready indicator.