发明授权
US09005575B2 Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
有权
用于诊断和治疗黑素瘤的Arg-Gly-Asp-共轭α-黑素细胞刺激激素杂交肽，包括转移性黑素瘤及与其相关的方法
- 专利标题： Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
- 专利标题（中）： 用于诊断和治疗黑素瘤的Arg-Gly-Asp-共轭α-黑素细胞刺激激素杂交肽，包括转移性黑素瘤及与其相关的方法
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申请号： US13321942申请日： 2010-05-28
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公开(公告)号： US09005575B2公开(公告)日： 2015-04-14
- 发明人: Yubin Miao , Jianquan Yang
- 申请人： Yubin Miao , Jianquan Yang
- 申请人地址： US NM Albuquerque
- 专利权人： STC.UNM
- 当前专利权人： STC.UNM
- 当前专利权人地址： US NM Albuquerque
- 代理商 Henry D. Coleman; R. Neil Sudol
- 国际申请： PCT/US2010/036686 WO 20100528
- 国际公布： WO2011/005380 WO 20110113
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61M36/14 ; C07K14/68 ; A61K51/08 ; C12N9/88 ; A61K38/00
摘要：
The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.