发明授权
- 专利标题: Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof
- 专利标题(中): 能够结合和中和乙型流感病毒的人结合分子及其用途
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申请号: US14323908申请日: 2014-07-03
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公开(公告)号: US09005621B2公开(公告)日: 2015-04-14
- 发明人: Ronald Vogels , Theodorus H. J. Kwaks
- 申请人: Crucell Holland B.V.
- 申请人地址: NL Leiden
- 专利权人: Crucell Holland B.V.
- 当前专利权人: Crucell Holland B.V.
- 当前专利权人地址: NL Leiden
- 代理机构: TraskBritt, P.C.
- 优先权: EP12158525 20120308
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A61K39/395 ; A61K39/42 ; A61K39/38 ; A61K39/145 ; C12Q1/70 ; C07K16/10 ; A61K47/48 ; G01N33/569
摘要:
Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses. These binding molecules do not bind to hemagglutinin of influenza A viruses. Further provided are nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis of, prophylaxis against, and/or treatment of influenza B virus infections.
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