Signals generated by radiation sensors can be encoded to reduce the number of cables needed to transport information from a nuclear imaging apparatus to a processor for reconstruction. For example, signals from 16 radiation sensors can be encoded into three signals: T (top), L (left), and E (energy). This method of encoding signals can be capable of substantially reducing the number of signals, thereby reducing costs. In addition, reducing the number of signals could improve system timing performance by eliminating cable time-skew and facilitate the filter design by downgrading the circuit accuracy requirements such as group-delay error and filter signal skews.