发明授权
US09011864B2 Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
有权
降低细胞毒性副作用并提高免疫缀合物功效的方法
- 专利标题： Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
- 专利标题（中）： 降低细胞毒性副作用并提高免疫缀合物功效的方法
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申请号： US12342180申请日： 2008-12-23
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公开(公告)号： US09011864B2公开(公告)日： 2015-04-21
- 发明人: Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
- 申请人： Gregor Schulz , Christoph Bruecher , Frank Osterroth , Steffen Zeng , Christoph Uherek , Silke Aigner , Benjamin Daelken , Markus Ruehle , Elmar Kraus
- 申请人地址： DE Dreieich US MA Waltham
- 专利权人： Biotest AG,Immunogen, Inc.
- 当前专利权人： Biotest AG,Immunogen, Inc.
- 当前专利权人地址： DE Dreieich US MA Waltham
- 代理机构： Agris & von Natzmer LLP
- 代理商 Joyce von Natzmer
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; A61K47/48 ; C07K16/28 ; B82Y5/00
摘要：
Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
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