公开(公告)号：US20090181038A1

公开(公告)日：2009-07-16

申请号：US12342180

申请日：2008-12-23

申请人： Gregor Schulz ,  Christoph Bruecher ,  Frank Osterroth ,  Steffen Zeng ,  Christoph Uherek ,  Silke Aigner ,  Benjamin Daelken ,  Markus Ruehle ,  Elmar Kraus

发明人： Gregor Schulz ,  Christoph Bruecher ,  Frank Osterroth ,  Steffen Zeng ,  Christoph Uherek ,  Silke Aigner ,  Benjamin Daelken ,  Markus Ruehle ,  Elmar Kraus

IPC分类号： A61K39/44

CPC分类号： C07K16/2896 ,  A61K39/39558 ,  A61K47/48561 ,  A61K47/48569 ,  A61K47/48723 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6891 ,  A61K2039/505 ,  A61K2300/00 ,  B82Y5/00 ,  C07K2317/24 ,  C07K2317/34

摘要： Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.

摘要翻译： 公开了用于改善免疫缀合物的靶向特别是肿瘤靶向的方法，组合物和试剂盒。 该方法和组合依赖于也表达免疫共轭靶标的非靶细胞的螯合。 公开了以各种方式封存那些非目标细胞。 方法，组合物和试剂盒允许非靶细胞的适当螯合，同时保持免疫缀合物对靶细胞的高度有效性。

公开(公告)号：US09011864B2

公开(公告)日：2015-04-21

申请号：US12342180

申请日：2008-12-23

申请人： Gregor Schulz ,  Christoph Bruecher ,  Frank Osterroth ,  Steffen Zeng ,  Christoph Uherek ,  Silke Aigner ,  Benjamin Daelken ,  Markus Ruehle ,  Elmar Kraus

发明人： Gregor Schulz ,  Christoph Bruecher ,  Frank Osterroth ,  Steffen Zeng ,  Christoph Uherek ,  Silke Aigner ,  Benjamin Daelken ,  Markus Ruehle ,  Elmar Kraus

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  C07K16/28 ,  B82Y5/00

CPC分类号： C07K16/2896 ,  A61K39/39558 ,  A61K47/48561 ,  A61K47/48569 ,  A61K47/48723 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6891 ,  A61K2039/505 ,  A61K2300/00 ,  B82Y5/00 ,  C07K2317/24 ,  C07K2317/34

摘要： Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.

摘要翻译： 公开了用于改善免疫缀合物的靶向特别是肿瘤靶向的方法，组合物和试剂盒。 该方法和组合依赖于也表达免疫共轭靶标的非靶细胞的螯合。 公开了以各种方式封存那些非目标细胞。 方法，组合物和试剂盒允许非靶细胞的适当螯合，同时保持免疫缀合物对靶细胞的高度有效性。

公开(公告)号：US07140669B2

公开(公告)日：2006-11-28

申请号：US10514109

申请日：2003-03-19

申请人： Walter Bollinger ,  Spencer Mckellip ,  Markus Ruehle

发明人： Walter Bollinger ,  Spencer Mckellip ,  Markus Ruehle

IPC分类号： B60J7/00

CPC分类号： B62D21/15 ,  B62D21/02 ,  B62D33/067

摘要： For the creation of a retainer is created between the driver's cab and the frame of a vehicle with a spring-loaded support that permits the displacement driver's cab, and with a connecting element by way of which the driver-side support connects to the frame, such retainer to ensure highest possible occupant safety as well as the safety of third parties while permitting low-cost production, a catch plate is proposed one end of which is attached to the connecting element while its other end is attached to the frame is proposed.

摘要翻译： 为了在驾驶室和具有允许排量驾驶室的弹簧加载的支撑件之间产生保持器的创建，并且具有驱动器侧支撑件连接到框架的连接元件， 这样的保持器，以确保尽可能高的乘客安全性以及第三方的安全性，同时允许低成本的生产，其中一端附接到连接元件，同时其另一端附接到框架被提出。

公开(公告)号：US20050225119A1

公开(公告)日：2005-10-13

申请号：US10514109

申请日：2003-03-19

申请人： Walter Bollinger ,  Spencer Mckellip ,  Markus Ruehle

发明人： Walter Bollinger ,  Spencer Mckellip ,  Markus Ruehle

IPC分类号： B62D21/02 ,  B62D21/15 ,  B62D33/067 ,  B62D33/06

CPC分类号： B62D21/15 ,  B62D21/02 ,  B62D33/067

摘要： A retainer is created between the driver's cab and the frame of a vehicle with a spring-loaded support that permits the displacement of the driver's cab, and with a connecting element by way of which the driver-side support connects to the frame. In order for such retainer to ensure highest possible occupant safety as well as the safety of third parties while permitting low-cost production, a catch plate having one end is attached to the connecting element and its other end is attached to the frame is proposed.

摘要翻译： 在驾驶室和车辆框架之间产生一个保持架，该保持架具有允许驾驶室的位移的弹簧加载的支撑件，以及驱动器侧支撑件连接到框架的连接元件。 为了使这种保持架能够确保尽可能高的乘客安全性和第三方的安全性，同时允许低成本生产，具有一端的卡扣附接到连接元件，并且其另一端附接到框架。