Invention Grant
- Patent Title: Modulators of alpha-synuclein toxicity
- Patent Title (中): α-突触核蛋白毒性的调节剂
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Application No.: US11914167Application Date: 2006-05-12
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Publication No.: US09018003B2Publication Date: 2015-04-28
- Inventor: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar
- Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2006/018908 WO 20060512
- International Announcement: WO2006/124892 WO 20061123
- Main IPC: C12N5/02
- IPC: C12N5/02 ; A61K38/17 ; G01N33/68
Abstract:
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Public/Granted literature
- US20090304664A1 MODULATORS OF ALPHA-SYNUCLEIN TOXICITY Public/Granted day:2009-12-10
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