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公开(公告)号：US20090099069A1
公开(公告)日：2009-04-16
申请号：US11720586
申请日：2005-12-01
Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
Inventor： Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
CPC classification number: C12Q1/6876 , G01N33/5014 , G01N33/5023 , G01N2500/00
Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了用于调节在高尔基体运输的ER步骤中起作用的基因表达的组合物和方法。 调节这些编码蛋白质活性基因表达的化合物可用于抑制α-突触核蛋白介导的毒性，并用于预防突触核蛋白病如帕金森病的威胁。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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公开(公告)号：US08399241B2
公开(公告)日：2013-03-19
申请号：US11720586
申请日：2005-12-01
Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
Inventor： Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar , Antony A. Cooper , Cole M. Haynes
IPC: C12N1/16
CPC classification number: C12Q1/6876 , G01N33/5014 , G01N33/5023 , G01N2500/00
Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了用于调节在高尔基体运输的ER步骤中起作用的基因表达的组合物和方法。 调节这些编码蛋白质活性基因表达的化合物可用于抑制α-突触核蛋白介导的毒性，并用于预防突触核蛋白病如帕金森病的威胁。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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3.发明申请Modulators of TDP-43 Mediated Toxicity and Methods of Use Thereof for Identifying Agents Having Efficacy for the Treatment and Prevention of Proteinopathies 有权TDP-43介导的毒性调节剂及其使用方法，用于鉴定具有治疗和预防蛋白质病症的药剂公开(公告)号：US20120237499A1
公开(公告)日：2012-09-20
申请号：US13260492
申请日：2010-03-26
Applicant: Aaron D. Gitler , Andrew Elden
Inventor： Aaron D. Gitler , Andrew Elden
IPC: A61K39/395 , A61P43/00 , A61K31/713 , A61K38/02 , C12N1/19 , C40B30/06
CPC classification number: A61K31/7088 , C12N15/113 , C12N2310/14
Abstract: Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.
Abstract translation: 公开了用于鉴定可用于治疗蛋白病的药剂的组合物和方法。
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4.发明申请Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis 审中-公开用于诊断和治疗肌萎缩性侧索硬化的组合物和方法公开(公告)号：US20110142789A1
公开(公告)日：2011-06-16
申请号：US12965618
申请日：2010-12-10
Applicant: Aaron D. Gitler , Nancy Bonini
Inventor： Aaron D. Gitler , Nancy Bonini
CPC classification number: C12Q1/6883 , C12Q1/6876 , C12Q2600/136 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N2500/10 , G01N2800/28 , G01N2800/50
Abstract: Compositions and methods for diagnosis and treatment of ALS are provided.
Abstract translation: 提供ALS诊断和治疗的组成和方法。
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公开(公告)号：US20110064722A1
公开(公告)日：2011-03-17
申请号：US12809859
申请日：2008-12-22
Applicant: Susan L. Lindquist , Aaron D. Gitler
Inventor： Susan L. Lindquist , Aaron D. Gitler
IPC: A61K39/395 , C12N5/071 , C12Q1/02 , C12Q1/68 , C12N5/10 , C12N1/19 , G01N33/53 , A61K31/7088 , A61K38/02 , G01N33/68 , C07K16/18 , C07H21/00 , A61P25/00 , A61P25/28 , A61P25/16
CPC classification number: C12Q1/025 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N2333/47 , G01N2500/10
Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了当在表达α-突触核蛋白的细胞中过表达时抑制或增强α-突触核蛋白介导的细胞毒性的基因。 调节这些基因表达或编码蛋白活性的化合物可用于抑制α-突触核蛋白介导的毒性，并用于治疗或预防突触核蛋白病如帕金森病。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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Patent Agency Ranking
公开(公告)号：US09738898B2
公开(公告)日：2017-08-22
申请号：US12867724
申请日：2009-02-13
Applicant: Susan L. Lindquist , Aaron D. Gitler
Inventor： Susan L. Lindquist , Aaron D. Gitler
CPC classification number: C12N15/81 , C12N15/1079 , G01N33/6872 , G01N33/6896 , G01N2500/10
Abstract: Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of the formation or maintenance of cytoplasmic inclusions of TDP-43. Compounds identified by such screens can be used to treat or prevent TDP-43 proteinopathies such as frontotemporal lobar degeneration or amyotrophic lateral sclerosis.
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7.发明授权Gene targets associated with amyotrophic lateral sclerosis and methods of use thereof 有权与肌萎缩性侧索硬化有关的基因靶点及其使用方法公开(公告)号：US08969005B2
公开(公告)日：2015-03-03
申请号：US13638237
申请日：2011-03-28
Applicant: Aaron D. Gitler
Inventor： Aaron D. Gitler
CPC classification number: C12Q1/6883 , C07K14/47 , C12Q2600/142 , C12Q2600/156 , G01N33/5014 , G01N2500/02 , G01N2800/2835 , G01N2800/50
Abstract: Compositions and methods for diagnosis and treatment of ALS are provided.
Abstract translation: 提供ALS诊断和治疗的组成和方法。
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8.发明授权公开(公告)号：US08865411B2
公开(公告)日：2014-10-21
申请号：US13260492
申请日：2010-03-26
Applicant: Aaron D. Gitler , Andrew Elden
Inventor： Aaron D. Gitler , Andrew Elden
IPC: C12Q1/68 , G01N33/53 , G01N33/567 , C07H21/02
CPC classification number: A61K31/7088 , C12N15/113 , C12N2310/14
Abstract: Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.
Abstract translation: 公开了用于鉴定可用于治疗蛋白病的药剂的组合物和方法。
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公开(公告)号：US09018003B2
公开(公告)日：2015-04-28
申请号：US11914167
申请日：2006-05-12
Applicant: Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar
Inventor： Susan L. Lindquist , Aaron D. Gitler , Anil Cashikar
CPC classification number: C12N15/113 , A61K38/1709 , C12N15/1086 , G01N33/6896 , G01N2500/00 , G01N2800/2821 , G01N2800/2835
Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Abstract translation: 公开了当在表达α-突触核蛋白的细胞中过表达时抑制或增强α-突触核蛋白介导的细胞毒性的基因。 调节这些基因表达或编码蛋白活性的化合物可用于抑制α-突触核蛋白介导的毒性，并用于治疗或预防突触核蛋白病如帕金森病。 还公开了鉴定α-突触核蛋白介导的毒性抑制剂的方法。
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公开(公告)号：US08501465B2
公开(公告)日：2013-08-06
申请号：US12809859
申请日：2008-12-22
Applicant: Susan L. Lindquist , Aaron D. Gitler
Inventor： Susan L. Lindquist , Aaron D. Gitler
CPC classification number: C12Q1/025 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N2333/47 , G01N2500/10
Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
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