发明授权
- 专利标题： Bicyclic heterocycle compounds and their uses in therapy
- 专利标题（中）： 双环杂环化合物及其在治疗中的应用
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申请号： US14112597申请日： 2012-04-20
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公开(公告)号： US09018214B2公开(公告)日： 2015-04-28
- 发明人: Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
- 申请人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
- 申请人地址： GB Cambridge
- 专利权人： Astex Therapeutics Limited
- 当前专利权人： Astex Therapeutics Limited
- 当前专利权人地址： GB Cambridge
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 优先权： GB1106817.8 20110421
- 国际申请： PCT/GB2012/050867 WO 20120420
- 国际公布： WO2012/143726 WO 20121026
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; A61K31/501 ; C07D403/04 ; C07D419/00 ; C07D403/14 ; C07D401/06 ; C07D471/04 ; C07D471/10 ; C07D403/06 ; C07D487/10
摘要：
The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
公开/授权文献
- US20140179666A1 BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY 公开/授权日：2014-06-26
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