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公开(公告)号:US20140179666A1
公开(公告)日:2014-06-26
申请号:US14112597
申请日:2012-04-20
申请人: Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
发明人: Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号: C07D471/04 , C07D403/14 , C07D487/10 , C07D403/06 , C07D471/10
CPC分类号: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及式(I)的双环杂环化合物:或互变异构体或立体化学异构形式,N-氧化物,药学上可接受的盐或其溶剂合物; 其中R1,R2a,R2b,R3a,R3b,R5,R6,R7,R8,R9,p和E如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号:US09018214B2
公开(公告)日:2015-04-28
申请号:US14112597
申请日:2012-04-20
申请人: Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
发明人: Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号: A61K31/497 , A61K31/501 , C07D403/04 , C07D419/00 , C07D403/14 , C07D401/06 , C07D471/04 , C07D471/10 , C07D403/06 , C07D487/10
CPC分类号: C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要: The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及式(I)的双环杂环化合物:或互变异构体或立体化学异构形式,N-氧化物,药学上可接受的盐或其溶剂合物; 其中R1,R2a,R2b,R3a,R3b,R5,R6,R7,R8,R9,p和E如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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3.Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases 有权
标题翻译: 咪唑并吡啶衍生物作为受体酪氨酸激酶的抑制剂公开(公告)号:US08796244B2
公开(公告)日:2014-08-05
申请号:US12997754
申请日:2009-06-12
申请人: Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud , Marian Williams
发明人: Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
IPC分类号: A61K31/5025 , C07D413/02
CPC分类号: C07D471/04 , C07D513/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的双环杂环衍生物化合物,包含该化合物的药物组合物和该化合物在治疗疾病中的用途。 癌症。
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4.IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES 有权
标题翻译: 作为受体酪氨酸激酶抑制剂的咪唑吡啶衍生物公开(公告)号:US20120208791A1
公开(公告)日:2012-08-16
申请号:US12997754
申请日:2009-06-12
申请人: Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Marian Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
发明人: Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Marian Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
IPC分类号: A61K31/437 , A61K31/501 , A61P35/00 , C07D513/04 , A61K31/53 , A61K31/506 , C07D471/04 , A61K31/5377
CPC分类号: C07D471/04 , C07D513/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的双环杂环衍生物化合物,包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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5.
公开(公告)号:US20100331296A1
公开(公告)日:2010-12-30
申请号:US12682508
申请日:2008-10-10
申请人: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
发明人: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
IPC分类号: A61K31/437 , C07D471/04 , A61P35/00
CPC分类号: C07D471/04 , C07D487/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及式(I)的新的双环杂环衍生物化合物:其中R1,A,X1,X2,X3,X4,X5和R2如本文所定义,包含所述化合物的药物组合物和所述化合物在 疾病的治疗,例如 癌症。
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公开(公告)号:US08513276B2
公开(公告)日:2013-08-20
申请号:US12520333
申请日:2007-12-21
申请人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
发明人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC分类号: C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04 , C07D487/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
摘要翻译: 本发明涉及式(I)的新的双环杂环衍生物化合物,包含所述化合物的药物组合物以及所述化合物在治疗疾病中的用途。 癌症。 式(I)的化合物是FGFR,VEGFR或PDGFR的抑制剂。
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公开(公告)号:US20100120761A1
公开(公告)日:2010-05-13
申请号:US12520481
申请日:2007-12-21
申请人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , MIles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
发明人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , MIles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC分类号: A61K31/437 , C07D471/04 , C07D487/04 , A61K31/496 , A61K31/5377 , A61K31/519 , A61P35/00
CPC分类号: C07D487/04 , A61K31/437 , C07D471/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的双环杂环衍生物化合物,包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号:US20100093718A1
公开(公告)日:2010-04-15
申请号:US12520333
申请日:2007-12-21
申请人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
发明人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC分类号: A61K31/5377 , C07D401/14 , A61K31/496 , C07D413/14 , C07D471/02 , A61K31/437 , C07D487/02 , A61K31/519 , A61P35/00
CPC分类号: C07D471/04 , C07D487/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
摘要翻译: 本发明涉及式(I)的新的双环杂环衍生物化合物,包含所述化合物的药物组合物以及所述化合物在治疗疾病中的用途。 癌症化学式(I)的化合物是FGFR,VEGFR或PDGFR的抑制剂。
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公开(公告)号:US08895745B2
公开(公告)日:2014-11-25
申请号:US12520481
申请日:2007-12-21
申请人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
发明人: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC分类号: C07D471/04 , A61K31/437 , C07D487/04
CPC分类号: C07D487/04 , A61K31/437 , C07D471/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及新的双环杂环衍生物化合物,包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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10.
公开(公告)号:US08076354B2
公开(公告)日:2011-12-13
申请号:US12682508
申请日:2008-10-10
申请人: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
发明人: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
IPC分类号: A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02
CPC分类号: C07D471/04 , C07D487/04
摘要: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译: 本发明涉及式(I)的新的双环杂环衍生物化合物:其中R1,A,X1,X2,X3,X4,X5和R2如本文所定义,包含所述化合物的药物组合物和所述化合物在 疾病的治疗,例如 癌症。
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