An output buffer is provided. The output buffer is coupled to a first voltage source providing a first supply voltage and used for generating an output signal at an output terminal according to an input signal. The output buffer includes first and second transistors and a self-bias circuit. The first and second transistors are cascaded between the output terminal and a reference voltage. The self-bias circuit is coupled to the output terminal and the control electrode of the first transistor. When the output buffer does not receive the first supply voltage, the self-bias circuit provides a first bias voltage to the control electrode of the first transistor according to the output signal to decrease voltage differences between the control electrode and the input and output electrodes of the first transistor to be lower than a predetermined voltage.