发明授权
- 专利标题: 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same
- 专利标题(中): 5元含氮杂环衍生物和包含它们的药物组合物
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申请号: US13494380申请日: 2012-06-12
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公开(公告)号: US09023882B2公开(公告)日: 2015-05-05
- 发明人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人地址: JP Matsumoto-shi
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Matsumoto-shi
- 代理机构: Westerman, Hattori, Daniels & Adrian, LLP
- 优先权: JP2007-104094 20070411
- 主分类号: A61K31/4025
- IPC分类号: A61K31/4025 ; C07D231/10 ; C07D207/30 ; A61K31/4155 ; C07D403/04 ; A61K31/402 ; A61K31/165 ; A61K31/404 ; A61K31/415 ; A61K31/427 ; A61K31/4439 ; A61K31/454 ; A61K31/5377 ; A61K45/06 ; C07D207/34 ; C07D231/14 ; C07D231/16 ; C07D231/20 ; C07D231/38 ; C07D231/40 ; C07D401/04 ; C07D405/04 ; C07D405/06 ; C07D409/04 ; C07D409/12 ; C07D417/04
摘要:
5-membered heterocyclic derivatives represented by general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, haloalkyl and the like; X1 and X2 independently represent CR2 or N; R2 represents H, alkyl and the like; R1 represents halogen, cyano, haloalkyl, A-D-E-G-L-M, —N(-D-L-M)2 and the like, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SO2 and the like.
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