发明授权
US09029553B2 2-anilino nicotinyl linked 2-amino benzothiazole conjugates and process for the preparation thereof
有权
2-苯胺基烟酰基连接的2-氨基苯并噻唑缀合物及其制备方法
- 专利标题： 2-anilino nicotinyl linked 2-amino benzothiazole conjugates and process for the preparation thereof
- 专利标题（中）： 2-苯胺基烟酰基连接的2-氨基苯并噻唑缀合物及其制备方法
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申请号： US13985417申请日： 2011-03-30
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公开(公告)号： US09029553B2公开(公告)日： 2015-05-12
- 发明人: Ahmed Kamal , Yellamelli Valli Venkata Srikanth , Mohammed Naseer Ahmed Khan , Mohammed Ashraf , Irum Sehar , Gousia Chashoo , Parduman Raj Sharma , Abid Hamid Dar , Bhushan Shashi , Shashank Kumar Singh , Dilip Manikrao Mondhe , Ajit Kumar Saxena
- 申请人： Ahmed Kamal , Yellamelli Valli Venkata Srikanth , Mohammed Naseer Ahmed Khan , Mohammed Ashraf , Irum Sehar , Gousia Chashoo , Parduman Raj Sharma , Abid Hamid Dar , Bhushan Shashi , Shashank Kumar Singh , Dilip Manikrao Mondhe , Ajit Kumar Saxena
- 申请人地址： IN
- 专利权人： Council of Scientific & Industrial Research
- 当前专利权人： Council of Scientific & Industrial Research
- 当前专利权人地址： IN
- 代理机构： St. Onge Steward Johnston & Reens LLC
- 优先权： IN373/DEL/2011 20110214
- 国际申请： PCT/IN2011/000217 WO 20110330
- 国际公布： WO2012/111016 WO 20120823
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; A61K31/4439 ; A61P35/00
摘要：
The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1═H or Cl; R2═H, OCH3 or F; R3═H, OCH3, F or Cl; R4═H, OCH3 or F and X═OCH3, F or N02.
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