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1.发明授权2-anilino nicotinyl linked 2-amino benzothiazole conjugates and process for the preparation thereof 有权2-苯胺基烟酰基连接的2-氨基苯并噻唑缀合物及其制备方法公开(公告)号：US09029553B2
公开(公告)日：2015-05-12
申请号：US13985417
申请日：2011-03-30
申请人： Ahmed Kamal , Yellamelli Valli Venkata Srikanth , Mohammed Naseer Ahmed Khan , Mohammed Ashraf , Irum Sehar , Gousia Chashoo , Parduman Raj Sharma , Abid Hamid Dar , Bhushan Shashi , Shashank Kumar Singh , Dilip Manikrao Mondhe , Ajit Kumar Saxena
发明人： Ahmed Kamal , Yellamelli Valli Venkata Srikanth , Mohammed Naseer Ahmed Khan , Mohammed Ashraf , Irum Sehar , Gousia Chashoo , Parduman Raj Sharma , Abid Hamid Dar , Bhushan Shashi , Shashank Kumar Singh , Dilip Manikrao Mondhe , Ajit Kumar Saxena
IPC分类号： C07D417/12 , A61K31/4439 , A61P35/00
CPC分类号： C07D417/12
摘要： The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1═H or Cl; R2═H, OCH3 or F; R3═H, OCH3, F or Cl; R4═H, OCH3 or F and X═OCH3, F or N02.
摘要翻译： 本发明提供了可用作抗人癌细胞系和凋亡诱导剂的潜在抗癌剂的通式A化合物。 本发明还提供了制备通式（A）的2-苯胺基烟酰基连接的2-氨基苯并噻唑缀合物的方法，其中R 1 = H或Cl; R2 = H，OCH3或F; R3 = H，OCH3，F或Cl; R4 = H，OCH3或F，X = OCH3，F或NO2。
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2.发明申请2-ANILINO NICOTINYL LINKED 2-AMINO BENZOTHIAZOLE CONJUGATES AND PROCESS FOR THE PREPARATION THEREOF 有权2-ANILINO NICOTINYL连接的2-氨基苯并噻唑联合物及其制备方法公开(公告)号：US20130324734A1
公开(公告)日：2013-12-05
申请号：US13985417
申请日：2011-03-30
申请人： Ahmed Kamal , Yellamelli Valli Venkata Srikanth , Mohammed Naseer Ahmed Khan , Mohammed Ashraf , Irum Sehar , Gousia Chashoo , Parduman Raj Sharma , Abid Hamid Dar , Bhushan Shashi , Shashank Kumar Singh , Dilip Manikrao Mondhe , Ajit Kumar Saxena
发明人： Ahmed Kamal , Yellamelli Valli Venkata Srikanth , Mohammed Naseer Ahmed Khan , Mohammed Ashraf , Irum Sehar , Gousia Chashoo , Parduman Raj Sharma , Abid Hamid Dar , Bhushan Shashi , Shashank Kumar Singh , Dilip Manikrao Mondhe , Ajit Kumar Saxena
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R1═H or CI; R2═H, OCH3 or F; R3═H, OCH3, F or CI; R4═H, OCH3 or F and X═OCH3, F or N02.
摘要翻译： 本发明提供了可用作抗人癌细胞系和凋亡诱导剂的潜在抗癌剂的通式A化合物。 本发明还提供了制备通式（A）的2-苯胺基烟酰基连接的2-氨基苯并噻唑缀合物的方法，其中R1 = H或C1; R2 = H，OCH3或F; R3 = H，OCH3，F或C1; R4 = H，OCH3或F，X = OCH3，F或NO2。
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3.发明申请USE OF SEMI SYNTHETIC ANALOGUES OF BOSWELLIC ACIDS FOR ANTICANCER ACTIVITY 审中-公开硼酸酯用于抗病毒活性的半合成类似物的应用公开(公告)号：US20090298938A1
公开(公告)日：2009-12-03
申请号：US12401337
申请日：2009-03-10
申请人： Ghulam Nabi Qazi , Subhash Chandra Taneja , Jaswant Singh , Ajit Kumar Saxena , Vijay Kumar Sethi , Bhahwal Ali Shah , Bal Krishan Kapahi , Samar Singh Andotra , Ajay Kumar , Shashi Bhushan , Fayaz Malik , Dilip Manikrao Mondhe , Shanmugavel Muthiah , Surjeet Singh , Monika Verma , Shashank Kumar Singh
发明人： Ghulam Nabi Qazi , Subhash Chandra Taneja , Jaswant Singh , Ajit Kumar Saxena , Vijay Kumar Sethi , Bhahwal Ali Shah , Bal Krishan Kapahi , Samar Singh Andotra , Ajay Kumar , Shashi Bhushan , Fayaz Malik , Dilip Manikrao Mondhe , Shanmugavel Muthiah , Surjeet Singh , Monika Verma , Shashank Kumar Singh
CPC分类号： A61K31/19
摘要： The present invention relates to use of compounds of general formula 1 for anticancerous activity, wherein the said compound being derived semi-synthetically from natural triterpenoic acids known as boswellic acids by the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analogues of natural triterpenes, known as Boswellic acids. These compounds may be used for the treatment of cancer, alone or in combination with pharmaceutically acceptable or other carriers, displaying cytotoxicity and anti-cancer activity for colon, prostrate, liver, breast, central nervous system (CNS), leukemia and malignancy of other tissues, including ascites and solid tumors. The cancer cell death is mediated by induction of apoptosis and inhibition of cell proliferation at specific doses.
摘要翻译： 本发明涉及通式1的化合物用于抗癌活性的用途，其中所述化合物通过诱导其细胞凋亡的细胞毒性和半合成显示的抗癌活性而被天然三萜烯酸被称为保乳酸半合成衍生 天然三萜类似物，称为乳香酸。 这些化合物可以单独使用或与药学上可接受的或其它载体组合用于治疗癌症，显示对结肠，前列腺癌，肝癌，乳腺癌，中枢神经系统（CNS），白血病和其他恶性肿瘤的细胞毒性和抗癌活性 组织，包括腹水和实体瘤。 癌细胞死亡是通过细胞凋亡的诱导和特定剂量的细胞增殖抑制来介导的。
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4.发明申请Hepatocurative effect of emblica officinalis against CYP 450 bio-activation hepatotoxicity of drugs 审中-公开对药物对CYP 450生物活化肝毒性的肝胆管作用公开(公告)号：US20080138452A1
公开(公告)日：2008-06-12
申请号：US12004403
申请日：2007-12-21
申请人： Rakesh Kamal Johri , Sheikh Tasaduq Abdullah , Kuldeep Singh , Devinder Kumar Gupta , Bal Krishan Kapahi , Dilip Manikrao Mondhe , Satinder Mohan Jain , Om Parkash Suri , Kasturi Lal Bedi , Ghulam Nabi Qazi
发明人： Rakesh Kamal Johri , Sheikh Tasaduq Abdullah , Kuldeep Singh , Devinder Kumar Gupta , Bal Krishan Kapahi , Dilip Manikrao Mondhe , Satinder Mohan Jain , Om Parkash Suri , Kasturi Lal Bedi , Ghulam Nabi Qazi
CPC分类号： A61K36/47 , A61K2300/00
摘要： The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity
摘要翻译： 本发明涉及一种可用于对由药物诱导的CYP 450生物活化肝毒性的肝脏作用的组合物，所述组合物包含来自Emblica officinalis的提取物和任选的药学上可接受的添加剂和治疗药物诱导的肝毒性的方法
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5.发明授权Hepatocurative effect of emblica officinalis against CYP 450 bio-activation hepatotoxicity of drugs 有权对药物对CYP 450生物活化肝毒性的肝胆管作用公开(公告)号：US07001619B2
公开(公告)日：2006-02-21
申请号：US10106119
申请日：2002-03-27
申请人： Rakesh Kamal Johri , Sheikh Tasaduq Abdullah , Kuldeep Singh , Devinder Kumar Gupta , Bal Krishan Kapahi , Dilip Manikrao Mondhe , Satinder Mohan Jain , Om Parkash Suri , Kasturi Lal Bedi , Ghulam Nabi Qazi
发明人： Rakesh Kamal Johri , Sheikh Tasaduq Abdullah , Kuldeep Singh , Devinder Kumar Gupta , Bal Krishan Kapahi , Dilip Manikrao Mondhe , Satinder Mohan Jain , Om Parkash Suri , Kasturi Lal Bedi , Ghulam Nabi Qazi
CPC分类号： A61K36/47 , A61K2300/00
摘要： The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity.
摘要翻译： 本发明涉及一种可用于对由药物诱导的CYP 450生物活化肝毒性的肝脏作用的组合物，所述组合物包含来自Emblica officinalis的提取物和任选的药学上可接受的添加剂和治疗药物诱导的肝毒性的方法。
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