发明授权
US09040524B2 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives
有权
抗真菌剂5,6-二氢-4H-吡咯并[1,2-a] [1,4] - 苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂卓
![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives](/docs/US/2015-05-26/US09040524B2/abs.jpg.600x600.jpg)
- 专利标题： Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives
- 专利标题（中）： 抗真菌剂5,6-二氢-4H-吡咯并[1,2-a] [1,4] - 苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂卓
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申请号： US13995526申请日： 2011-12-19
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公开(公告)号： US09040524B2公开(公告)日： 2015-05-26
- 发明人: Lieven Meerpoel , Louis Jules Roger Marie Maes , Kelly de Wit
- 申请人： Lieven Meerpoel , Louis Jules Roger Marie Maes , Kelly de Wit
- 申请人地址： BE Beerse
- 专利权人： JANSSEN PHARMACEUTICA NV
- 当前专利权人： JANSSEN PHARMACEUTICA NV
- 当前专利权人地址： BE Beerse
- 代理商 Thomas J. Dodd
- 优先权： EP10196201 20101221
- 国际申请： PCT/EP2011/073215 WO 20111219
- 国际公布： WO2012/084804 WO 20120628
- 主分类号： A61K31/5517
- IPC分类号： A61K31/5517 ; C07D487/04
![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives](/abs-image/US/2015/05/26/US09040524B2/abs.jpg.150x150.jpg)
摘要：
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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