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![Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-α][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-α][1,4]benzodiazepine derivatives](/abs-image/US/2017/05/02/US09637490B2/abs.jpg.150x150.jpg)
公开(公告)号：US09637490B2
公开(公告)日：2017-05-02
申请号：US13702361
申请日：2011-06-01
IPC分类号： C07D487/12 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention concerns novel compounds of Formula (I): wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES](/abs-image/US/2013/04/04/US20130085136A1/abs.jpg.150x150.jpg)
2.发明申请NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES 有权新的反式5,6-二羟基-4 - [（二氟乙基）苯基] -4H-吡咯并[1,2-a] [1,4]苯并嗪和4-（二氟乙基）苯基-6H-吡咯并[1,2-a ] [1,4]苯并咪唑衍生物公开(公告)号：US20130085136A1
公开(公告)日：2013-04-04
申请号：US13702361
申请日：2011-06-01
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention concerns novel compounds of Formula (I): wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及新的式（I）化合物：其中R1，R2，R3，R4，R5和R6具有权利要求中限定的含义。 根据本发明的化合物主要是抗皮肤癣菌和全身真菌感染的活性物质。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives](/abs-image/US/2016/11/15/US09493468B2/abs.jpg.150x150.jpg)
3.发明授权Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzo-diazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives 有权抗真菌剂5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6-吡咯并[1,2-a]公开(公告)号：US09493468B2
公开(公告)日：2016-11-15
申请号：US14113356
申请日：2012-05-03
IPC分类号： A61K31/551 , C07D487/04 , A61K9/28 , A61K9/48
CPC分类号： C07D487/04 , A61K9/2866 , A61K9/4866
摘要： The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives](/abs-image/US/2015/05/26/US09040524B2/abs.jpg.150x150.jpg)
4.发明授权Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives 有权抗真菌剂5,6-二氢-4H-吡咯并[1,2-a] [1,4] - 苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂卓公开(公告)号：US09040524B2
公开(公告)日：2015-05-26
申请号：US13995526
申请日：2011-12-19
IPC分类号： A61K31/5517 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及新颖的抗真菌5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂 其中R 1，R 2，R 3，R 4，R 5，R 6和R 7具有权利要求中定义的含义的式（I）的双环苯衍生物。 根据本发明的化合物主要是抗皮肤癣菌和全身真菌感染的活性物质。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES](/abs-image/US/2013/10/17/US20130274250A1/abs.jpg.150x150.jpg)
5.发明申请NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BENZENE DERIVATIVES 有权新颖的反式5,6-二氢-4H-吡咯并[1,2-a] [1,4] - 苯并吖庚因和6H-吡咯并[1,2-a] [1,4]苯并噻唑衍生物用苯并恶唑衍生物公开(公告)号：US20130274250A1
公开(公告)日：2013-10-17
申请号：US13989233
申请日：2011-11-18
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及新型抗真菌5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂 （I）其中R1，R2，R3，R4，R5和R6具有权利要求中限定的含义。 根据本发明的化合物主要是抗皮肤癣菌和全身真菌感染的活性物质。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES](/abs-image/US/2014/02/13/US20140045827A1/abs.jpg.150x150.jpg)
6.发明申请NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES 有权新颖的反式5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6H-吡咯[1,2-a] [1,4]苯并恶嗪衍生物用杂环衍生物取代公开(公告)号：US20140045827A1
公开(公告)日：2014-02-13
申请号：US14113356
申请日：2012-05-03
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K9/2866 , A61K9/4866
摘要： The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及新颖的抗真菌5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂 其中R1，R2，R3，R4和Het具有权利要求中限定的含义的式（I）的杂环衍生物。 根据本发明的化合物主要是抗皮肤癣菌和全身真菌感染的活性物质。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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![Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives](/abs-image/US/2015/05/26/US09040523B2/abs.jpg.150x150.jpg)
7.发明授权Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives 有权用苯衍生物取代的5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂卓和6H-吡咯并[1,2-a] [1,4]苯并二氮杂公开(公告)号：US09040523B2
公开(公告)日：2015-05-26
申请号：US13989233
申请日：2011-11-18
IPC分类号： A61K31/5517 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及新型抗真菌5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂 （I）其中R1，R2，R3，R4，R5和R6具有权利要求中限定的含义。 根据本发明的化合物主要是抗皮肤癣菌和全身真菌感染的活性物质。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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![NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES](/abs-image/US/2013/10/10/US20130267507A1/abs.jpg.150x150.jpg)
8.发明申请NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES 有权新型的反式5,6-二氢-4H-吡咯并[1,2-a] [1,4] - 苯并恶嗪衍生物和6H-吡咯并[1,2-a] [1,4]苯并二氮杂双环苯衍生物公开(公告)号：US20130267507A1
公开(公告)日：2013-10-10
申请号：US13995526
申请日：2011-12-19
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译： 本发明涉及新颖的抗真菌5,6-二氢-4H-吡咯并[1,2-a] [1,4]苯并二氮杂和6H-吡咯并[1,2-a] [1,4]苯并二氮杂 其中R 1，R 2，R 3，R 4，R 5，R 6和R 7具有权利要求中定义的含义的式（I）的双环苯衍生物。 根据本发明的化合物主要是抗皮肤癣菌和全身真菌感染的活性物质。 本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
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