A fastener cartridge can comprise a crushable cartridge body and fasteners embedded within the crushable cartridge body which can be utilized to fasten tissue. In use, the fastener cartridge can be positioned in a first jaw of a surgical fastening device, wherein the first jaw can be positioned opposite a second jaw, or anvil. The anvil can be engaged with the fastener cartridge to crush the cartridge body and deform, or otherwise deploy, the fasteners contained therein. As the fasteners are deformed or deployed, the fasteners can capture at least a portion of the cartridge body therein along with at least a portion of the tissue being fastened. A fastener cartridge can comprise a compressible cartridge body having a thickness which can be reduced by the compressive pressure applied by the anvil. In certain embodiments, a fastener cartridge can comprise a cartridge body which can collapse from the compressive pressure.