发明授权
- 专利标题: Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
- 专利标题(中): 具有在不同于互补决定区的分子区域中工程化的结合特性的合成免疫球蛋白结构域
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申请号: US13151195申请日: 2011-06-01
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公开(公告)号: US09045528B2公开(公告)日: 2015-06-02
- 发明人: Florian Ruker , Gottfried Himmler , Gordana Wozniak-Knopp
- 申请人: Florian Ruker , Gottfried Himmler , Gordana Wozniak-Knopp
- 申请人地址: AT Vienna
- 专利权人: F-star Biotechnologische Forschungs—und Entwicklungsges.m.b.H
- 当前专利权人: F-star Biotechnologische Forschungs—und Entwicklungsges.m.b.H
- 当前专利权人地址: AT Vienna
- 代理机构: Sunstein Kann Murphy & Timbers LLP
- 主分类号: C07K19/00
- IPC分类号: C07K19/00 ; C07K16/00
摘要:
A method of engineering immunoglobulins which each have one or more amino acid modifications in at least one structural loop region of such immunoglobulins, where the modified loop region specifically binds to an epitope of an antigen to which an unmodified immunoglobulin does not significantly bind.
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