Example microfluidic methods and apparatus to perform in situ chemical detection are disclosed. A disclosed example downhole apparatus comprises a microfluidic chamber to introduce a microfluidic-scale drop of a reagent into a formation fluid to form a mixed fluid, a flowline to fluidly couple the formation fluid from a geologic formation to the microfluidic chamber, and a detector to measure a property of the mixed fluid, the property representative of a presence of a chemical in the formation fluid.