发明授权
- 专利标题: Medical device with crystalline drug coating
- 专利标题(中): 医疗器械与结晶药物涂层
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申请号: US13242445申请日: 2011-09-23
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公开(公告)号: US09056152B2公开(公告)日: 2015-06-16
- 发明人: Steve Kangas , James Feng , Yen-Lane Chen , Maggie Zeng
- 申请人: Steve Kangas , James Feng , Yen-Lane Chen , Maggie Zeng
- 申请人地址: US MN Maple Grove
- 专利权人: Boston Scientific Scimed, Inc.
- 当前专利权人: Boston Scientific Scimed, Inc.
- 当前专利权人地址: US MN Maple Grove
- 代理机构: Vidas, Arrett & Steinkraus
- 主分类号: A61L33/00
- IPC分类号: A61L33/00 ; A61L27/54 ; A61L29/16 ; A61L31/16 ; A61K31/337 ; C09D5/16 ; A61F2/02 ; A61F2/00
摘要:
A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 μm or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.
公开/授权文献
- US20130053947A1 Medical Device with Crystalline Drug Coating 公开/授权日:2013-02-28