发明授权
- 专利标题: Substituted 6-aza-isoindolin-1-one derivatives
- 专利标题(中): 取代的6-氮杂 - 异吲哚啉-1-酮衍生物
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申请号: US14128576申请日: 2012-06-20
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公开(公告)号: US09056873B2公开(公告)日: 2015-06-16
- 发明人: Mitsunori Kono , Zhe Nie
- 申请人: Mitsunori Kono , Zhe Nie
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理商 Matthew J. Russo
- 国际申请: PCT/US2012/043276 WO 20120620
- 国际公布: WO2012/177714 WO 20121227
- 主分类号: A61K31/437
- IPC分类号: A61K31/437 ; C07D471/04 ; C07D498/04 ; C07D519/00 ; A61K31/4365 ; A61K31/4985 ; A61K31/519 ; A61K31/5383 ; C07D487/04 ; C07D495/04
摘要:
Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, p, R1, R2, R3a, R4, and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, cancer, and other disorders, diseases, and conditions for which inhibition of SYK is indicated.
公开/授权文献
- US20140206680A1 SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES 公开/授权日:2014-07-24
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