发明授权
- 专利标题: Delivery system for sustained release of a calcium-channel blocking agent
- 专利标题(中): 用于钙通道阻断剂持续释放的输送系统
-
申请号: US13500013申请日: 2010-10-05
-
公开(公告)号: US09060986B2公开(公告)日: 2015-06-23
- 发明人: Jorg Breitenbach , Bernd Liepold , Didier R. Lefebvre , Steffen Bossmann , Benedikt Steitz , Peter Hölig
- 申请人: Jorg Breitenbach , Bernd Liepold , Didier R. Lefebvre , Steffen Bossmann , Benedikt Steitz , Peter Hölig
- 申请人地址: AT Graz
- 专利权人: BDS Pharma GmbH
- 当前专利权人: BDS Pharma GmbH
- 当前专利权人地址: AT Graz
- 代理机构: Saul Ewing LLP
- 代理商 Peter C. Lauro, Esq.
- 优先权: EP09172370 20091006
- 国际申请: PCT/EP2010/064804 WO 20101005
- 国际公布: WO2011/042420 WO 20110414
- 主分类号: A61K31/4418
- IPC分类号: A61K31/4418 ; A61P25/00 ; A61K31/216 ; A61K9/00 ; A61K9/14
摘要:
A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.
公开/授权文献
信息查询
IPC分类: