发明授权
US09061014B2 Intravascular delivery of nanoparticle compositions and uses thereof
有权
纳米颗粒组合物的血管内递送及其用途
- 专利标题: Intravascular delivery of nanoparticle compositions and uses thereof
- 专利标题(中): 纳米颗粒组合物的血管内递送及其用途
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申请号: US14113568申请日: 2012-04-27
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公开(公告)号: US09061014B2公开(公告)日: 2015-06-23
- 发明人: Kirk Seward , Neil P. Desai
- 申请人: Kirk Seward , Neil P. Desai
- 申请人地址: US CA Los Angeles US CA San Leandro
- 专利权人: ABRAXIS BIOSCIENCE, LLC,MERCATOR MEDSYSTEMS, INC.
- 当前专利权人: ABRAXIS BIOSCIENCE, LLC,MERCATOR MEDSYSTEMS, INC.
- 当前专利权人地址: US CA Los Angeles US CA San Leandro
- 代理机构: Morrison & Foerster LLP
- 国际申请: PCT/US2012/035626 WO 20120427
- 国际公布: WO2012/149451 WO 20121101
- 主分类号: A61K31/436
- IPC分类号: A61K31/436 ; A61K9/00 ; A61K47/48 ; A61K38/38 ; A61M25/00
摘要:
The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases.
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