The present invention relates to a method and apparatus for generating a reference signal sequence in a wireless communication system. User equipment receives a cell-specific sequence hopping parameter from a base station, receives, from the base station, a user equipment (UE)-specific sequence group hopping (SGH) parameter which is specific to said user equipment, and generates a reference signal sequence on the basis of a base sequence number of a base sequence, wherein the base sequence number is determined for each slot on the basis of the cell-specific sequence hopping parameter and of the use equipment-specific sequence group hopping parameter. Here, the determination of whether or not to apply sequence hopping to the base sequence number indicated by the user equipment-specific sequence group hopping parameter overrides that of whether or not to apply sequence hopping to the base sequence number indicated by the cell-specific sequence hopping parameter.