发明授权
- 专利标题： Thiocarbon-protecting groups for RNA synthesis
- 专利标题（中）： 用于RNA合成的硫代保护基团
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申请号： US13485592申请日： 2012-05-31
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公开(公告)号： US09067961B2公开(公告)日： 2015-06-30
- 发明人: Douglas J. Dellinger , Agnieszka B. Sierzchala , John Turner , Joel Myerson , Zoltan Kupihar , Fernando Ferreira , Marvin H. Caruthers , Geraldine F. Dellinger
- 申请人： Douglas J. Dellinger , Agnieszka B. Sierzchala , John Turner , Joel Myerson , Zoltan Kupihar , Fernando Ferreira , Marvin H. Caruthers , Geraldine F. Dellinger
- 申请人地址： US CA Santa Clara US CO Denver
- 专利权人： Agilent Technologies, Inc.,The Regents of the University of Colorado Denver
- 当前专利权人： Agilent Technologies, Inc.,The Regents of the University of Colorado Denver
- 当前专利权人地址： US CA Santa Clara US CO Denver
- 主分类号： C07H13/12
- IPC分类号： C07H13/12 ; C07H21/02 ; C07H19/073 ; C07H19/16
摘要：
Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
公开/授权文献
- US20120238737A1 THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS 公开/授权日：2012-09-20