Invention Grant
US09072698B2 Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds
有权
用于筛选抑制TM4SF5功能的抗癌化合物的方法和含查耳酮化合物的抗癌组合物
- Patent Title: Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds
- Patent Title (中): 用于筛选抑制TM4SF5功能的抗癌化合物的方法和含查耳酮化合物的抗癌组合物
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Application No.: US13482568Application Date: 2012-05-29
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Publication No.: US09072698B2Publication Date: 2015-07-07
- Inventor: Ki Hun Park , Jung Weon Lee , Young Bae Ryu , Hyung Won Ryu , Sin-Ae Lee
- Applicant: Ki Hun Park , Jung Weon Lee , Young Bae Ryu , Hyung Won Ryu , Sin-Ae Lee
- Applicant Address: KR Seoul KR Gyeongsangnam-do
- Assignee: Seoul National University Industry Foundation,Industry-Academic Cooperation Foundation Gyeongsang National University
- Current Assignee: Seoul National University Industry Foundation,Industry-Academic Cooperation Foundation Gyeongsang National University
- Current Assignee Address: KR Seoul KR Gyeongsangnam-do
- Agency: Klarquist Sparkman, LLP
- Priority: KR10-2006-0124146 20061207
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; A61K31/135 ; C07C49/835 ; C07C49/84 ; C07C309/66 ; C07C309/73 ; C07C309/75 ; C07C309/76 ; C07C311/21 ; C07C311/29 ; C07C311/44 ; G01N33/50
Abstract:
The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.
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