发明授权
US09072718B2 Burdock fruit extract containing arctigenin and method for producing same
有权
含有赤霉素的牛蒡果实提取物及其制造方法
- 专利标题: Burdock fruit extract containing arctigenin and method for producing same
- 专利标题(中): 含有赤霉素的牛蒡果实提取物及其制造方法
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申请号: US13849302申请日: 2013-03-22
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公开(公告)号: US09072718B2公开(公告)日: 2015-07-07
- 发明人: Toshiki Okubo , Satoshi Yomoda , Takafumi Fuse , Takanori Kawashima , Hiroyasu Esumi , Chika Miyoshi , Shigetoshi Kadota
- 申请人: Kracie Pharma, Ltd. , National Cancer Center , National University Corporation University of Toyama
- 申请人地址: JP Toyama JP Tokyo JP Tokyo
- 专利权人: National University Corporation University of Toyama,Kracie Pharma, Ltd.,National Cancer Center
- 当前专利权人: National University Corporation University of Toyama,Kracie Pharma, Ltd.,National Cancer Center
- 当前专利权人地址: JP Toyama JP Tokyo JP Tokyo
- 代理机构: Sunstein Kann Murphy & Timbers LLP
- 优先权: JP2010-215118 20100927
- 主分类号: A01N65/00
- IPC分类号: A01N65/00 ; A61K36/28 ; A61K31/365 ; A61K31/7048 ; C07D307/33
摘要:
PROBLEM TO BE SOLVEDThe present invention is intended to provide a burdock fruit extract comprising arctigenin and arctiin at a definite ratio and a method for producing the same. More particularly, the present invention is intended to provide a method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of approximately 1:1.SOLUTIONA method for producing a burdock fruit extract comprising arctigenin and arctiin at a weight ratio of arctigenin/arctiin=0.7 to 1.3 is provided, including the steps of: cutting a burdock fruit and converting arctiin which is inherent in the burdock fruit into arctigenin by enzymatic conversion by beta-glucosidase which is inherent in the burdock fruit, wherein the enzymatic conversion includes reaction at a temperature from 20° C. to 50° C. Also provided is the method further including a step of extracting an extract comprising arctigenin and arctiin by adding an organic solvent and heating to reflux.
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