Invention Grant
US09075064B2 Method for decreasing radioresistance and growth, metastasis and infiltration of cancer cells through regulating expression or activity of TM4SF4 in non-small cell lung cancer
有权
通过调节非小细胞肺癌TM4SF4的表达或活性来降低癌细胞的放射抗性和生长，转移和浸润的方法
- Patent Title: Method for decreasing radioresistance and growth, metastasis and infiltration of cancer cells through regulating expression or activity of TM4SF4 in non-small cell lung cancer
- Patent Title (中): 通过调节非小细胞肺癌TM4SF4的表达或活性来降低癌细胞的放射抗性和生长，转移和浸润的方法
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Application No.: US14347506Application Date: 2011-10-21
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Publication No.: US09075064B2Publication Date: 2015-07-07
- Inventor: In-Gyu Kim , Soo Im Choi , Byung-Chul Shin
- Applicant: In-Gyu Kim , Soo Im Choi , Byung-Chul Shin
- Applicant Address: KR Daejeon
- Assignee: Korea Atomic Energy Research Institute
- Current Assignee: Korea Atomic Energy Research Institute
- Current Assignee Address: KR Daejeon
- Agency: Klarquist Sparkman, LLP
- Priority: KR10-2011-0096918 20110926
- International Application: PCT/KR2011/007900 WO 20111021
- International Announcement: WO2013/047941 WO 20130404
- Main IPC: A61K39/395
- IPC: A61K39/395 ; G01N33/574 ; A61K31/7105 ; A61K31/713 ; C12N15/113 ; C07K14/705 ; C07K16/30 ; C12Q1/68 ; G01N33/50 ; C07K16/28 ; A61K48/00
Abstract:
The present invention relates to a pharmaceutical composition or an anticancer agent for preventing and treating non-small cell lung cancer, containing a substance for regulating the expression or activity of transmembrane 4 L six family member 4 (TM4SF4). More specifically, the present invention relates to a use of a substance for regulating the expression or activity of TM4SF4 as an anticancer drug or an anticancer agent with respect to non-small cell lung cancer, wherein it was ascertained that it is possible to decrease the growth, metastasis, and infiltration of adenocarcinoma cells and radioresistance by decreasing the expression of TM4SF4 in adenocarcinoma among non-small cell lung cancers and to decrease the growth, metastasis, and infiltration of the cells and radioresistance by increasing the expression of TM4SF4 in other non-small cell lung cancers except adenocarcinoma.
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