发明授权
- 专利标题： Substituted triazole derivatives as gamma secretase modulators
- 专利标题（中）： 取代的三唑衍生物作为γ分泌酶调节剂
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申请号： US13522409申请日： 2011-01-12
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公开(公告)号： US09079886B2公开(公告)日： 2015-07-14
- 发明人: Sven Franciscus Anna Van Brandt , Michel Anna Jozef De Cleyn , Henricus Jacobus Maria Gijsen , Didier Jean-Claude Berthelot , Michel Surkyn
- 申请人： Sven Franciscus Anna Van Brandt , Michel Anna Jozef De Cleyn , Henricus Jacobus Maria Gijsen , Didier Jean-Claude Berthelot , Michel Surkyn
- 申请人地址： US NJ Titusville GB Brentford, Middlesex
- 专利权人： Janssen Pharmaceuticals, Inc.,Cellzome Limited
- 当前专利权人： Janssen Pharmaceuticals, Inc.,Cellzome Limited
- 当前专利权人地址： US NJ Titusville GB Brentford, Middlesex
- 代理机构： Baker & Hostetler LLP
- 优先权： EP10150892 20100115; EP10171292 20100729
- 国际申请： PCT/EP2011/050350 WO 20110112
- 国际公布： WO2011/086099 WO 20110721
- 主分类号： C07D401/10
- IPC分类号： C07D401/10 ; C07D401/14 ; C07D401/12 ; C07D413/10 ; C07D413/12 ; C07D413/14 ; C07D417/10 ; C07D417/12 ; C07D417/14 ; C07D403/14 ; C07D403/10 ; C07D403/12 ; C07D413/04
摘要：
The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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