发明授权
- 专利标题： Spiro-oxindole MDM2 antagonists
- 专利标题（中）： 螺羟吲哚MDM2拮抗剂
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申请号： US14485054申请日： 2014-09-12
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公开(公告)号： US09079913B2公开(公告)日： 2015-07-14
- 发明人: Shaomeng Wang , Shanghai Yu , Wei Sun , Sanjeev Kumar , Duxin Sun , Peng Zou , Donna McEachern , Yujun Zhao
- 申请人： The Regents of the University of Michigan
- 申请人地址： US MI Ann Arbor
- 专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人地址： US MI Ann Arbor
- 代理机构： Casimir Jones, S.C.
- 主分类号： C07D487/10
- IPC分类号： C07D487/10 ; A61K31/407 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; A61K31/675 ; A61K45/06 ; C07D491/107 ; C07D495/10 ; C07D471/20 ; C07F9/6561
摘要：
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
公开/授权文献
- US20140378680A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS 公开/授权日：2014-12-25
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