Invention Grant
US09080180B2 Transgenic plants expressing STX2EB protein for use as a pig edema disease vaccine
有权
表达STX2EB蛋白的转基因植物用作猪水肿病疫苗
- Patent Title: Transgenic plants expressing STX2EB protein for use as a pig edema disease vaccine
- Patent Title (中): 表达STX2EB蛋白的转基因植物用作猪水肿病疫苗
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Application No.: US12667393Application Date: 2008-03-25
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Publication No.: US09080180B2Publication Date: 2015-07-14
- Inventor: Kazutoshi Sawada , Kazuya Yoshida , Takeshi Matsui , Sou-ichi Makino , Keiko Kawamoto
- Applicant: Kazutoshi Sawada , Takeshi Matsui , Sou-ichi Makino , Keiko Kawamoto , Mayumi Yoshida , Nobuo Yoshida , Kyoko Yoshida
- Applicant Address: JP Tokyo JP Ikoma-shi JP Obihiro-shi
- Assignee: IDEMITSU KOSAN CO., LTD.,NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY,NATIONAL UNIVERSITY CORPORATION OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE
- Current Assignee: IDEMITSU KOSAN CO., LTD.,NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY,NATIONAL UNIVERSITY CORPORATION OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE
- Current Assignee Address: JP Tokyo JP Ikoma-shi JP Obihiro-shi
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007-174919 20070703
- International Application: PCT/JP2008/055550 WO 20080325
- International Announcement: WO2009/004842 WO 20090108
- Main IPC: C12N15/82
- IPC: C12N15/82 ; C12N15/30 ; A61K39/112 ; A61K39/108 ; A61K39/00
Abstract:
A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5′-untranslated region of an alcohol dehydrogenase gene (ADH5′UTR) derived from a plant.
Public/Granted literature
- US20110002950A1 PIG EDEMA DISEASE VACCINE Public/Granted day:2011-01-06
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