公开(公告)号：US20110231960A1

公开(公告)日：2011-09-22

申请号：US12990597

申请日：2009-04-28

申请人： Kazutoshi Sawada ,  Kazuya Yoshida ,  Mayumi Yoshida ,  Nobuo Yoshida ,  Kyoko Yoshida ,  Takeshi Matsui

发明人： Kazutoshi Sawada ,  Kazuya Yoshida ,  Mayumi Yoshida ,  Nobuo Yoshida ,  Kyoko Yoshida ,  Takeshi Matsui

IPC分类号： A01H5/00 ,  C12N15/63 ,  C07K19/00 ,  C07H21/04 ,  C12N5/10 ,  A01H5/10 ,  C07K7/08 ,  C07K14/00

CPC分类号： C07K14/245 ,  A61K39/00 ,  A61K39/0258 ,  A61K2039/517 ,  C07K14/25 ,  C07K14/28 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/8258 ,  Y02A50/472 ,  Y02A50/474

摘要： A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.

摘要翻译： 使用植物细胞有效地产生细菌毒素蛋白如志贺毒素蛋白质。 使用含有编码杂合蛋白的DNA的DNA构建体转化植物细胞，其中细菌毒素蛋白如志贺毒素蛋白通过具有以下特征（A）和（B）的肽串联连接以产生细菌毒素蛋白 在植物细胞中：（A）一些氨基酸为12〜30; （B）脯氨酸含量为20〜35％。

公开(公告)号：US20110002950A1

公开(公告)日：2011-01-06

申请号：US12667393

申请日：2008-03-25

申请人： Kazutoshi Sawada ,  Kazuya Yoshida ,  Mayumi Yoshida ,  Nobuo Yoshida ,  Kyoko Yoshida ,  Takeshi Matsui ,  Sou-ichi Makino ,  Keiko Kawamoto

发明人： Kazutoshi Sawada ,  Kazuya Yoshida ,  Mayumi Yoshida ,  Nobuo Yoshida ,  Kyoko Yoshida ,  Takeshi Matsui ,  Sou-ichi Makino ,  Keiko Kawamoto

IPC分类号： A61K39/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  A01H5/00

CPC分类号： C12N15/8258 ,  A61K39/0258 ,  A61K2039/517 ,  A61K2039/552 ,  C12N15/8257 ,  Y02A50/474

摘要： A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5′-untranslated region of an alcohol dehydrogenase gene (ADH5′UTR) derived from a plant.

摘要翻译： 开发了一种以低成本，高效率生产猪水肿病疫苗的技术。 具体地说，猪水肿病毒素蛋白（Stx2e蛋白）的基因在植物细胞中有效表达，以低成本生产猪水肿病植物疫苗。 使用源于植物的醇脱氢酶基因（ADH5'UTR）的5'-非翻译区，在植物如莴苣植物的细胞中表达包含衍生自在氨基末端添加的植物的分泌信号肽的Stx2e蛋白质。

公开(公告)号：US06642355B2

公开(公告)日：2003-11-04

申请号：US09750754

申请日：2001-01-02

申请人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

发明人： Takeo Tanaka ,  Yoshikazu Morishita ,  Mika Makino ,  Shigeru Chiba ,  Isao Kawamoto ,  Eiji Tsukuda ,  Mayumi Yoshida ,  Chieko Bando ,  Kazuo Yamaguchi ,  Yuzuru Matsuda ,  Shigeto Kitamura ,  Toshihide Ikemura ,  Tatsuhiro Ogawa ,  Keiichi Yano ,  Toshiyuki Suzawa ,  Kenji Shibata ,  Motoo Yamasaki

IPC分类号： C07K700

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/08 ,  C07K14/36 ,  C07K14/57536 ,  C12R1/465

摘要： The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y   (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or  and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及式（I）的内皮素拮抗肽：其中代表Asn或Asp; B代表His或Lys; E表示Ala或Ser; G表示Ala或Pro; X表示X 1 -Gly或Y表示羟基，低级烷氧基，氨基，其中X 1，X 3，Y 1，Y 2和Z进一步定义，或 其药学上可接受的盐。

公开(公告)号：US5857132A

公开(公告)日：1999-01-05

申请号：US935111

申请日：1997-09-29

申请人： Haruji Mizuishi ,  Hisashi Fuzisaki ,  Mayumi Yoshida ,  Kenji Karashima ,  Yasushi Akiba

发明人： Haruji Mizuishi ,  Hisashi Fuzisaki ,  Mayumi Yoshida ,  Kenji Karashima ,  Yasushi Akiba

IPC分类号： G03G15/02 ,  G03G15/00 ,  G03G15/16

CPC分类号： G03G15/1675 ,  G03G15/168 ,  G03G15/6535 ,  G03G2215/1652

摘要： A contact type image transferring system and method, incorporated in an image forming apparatus, for cleaning a residual toner on a transfer roller. The transfer roller is in contact with a photoconductive drum and forms a nip between the roller and the drum. A sheet of paper passes through the nip and a toner image on the drum is transferred to the sheet of paper. When the sheet of paper is not at the nip, not only a transfer voltage but also a charging voltage is applied at a same time. The polarities of the voltages applied to the charger and to the transfer roller cause the toner on the transfer roller to be removed.

摘要翻译： 一种接合型图像转印系统和方法，其结合在图像形成装置中，用于清洁转印辊上的残留调色剂。 转印辊与感光鼓接触并在辊和鼓之间形成辊隙。 一张纸通过辊隙，鼓上的调色剂图像被转印到纸张上。 当纸张不在辊隙时，不仅同时施加转印电压而且施加充电电压。 施加到充电器和转印辊上的电压的极性导致转印辊上的调色剂被去除。

公开(公告)号：US5236929A

公开(公告)日：1993-08-17

申请号：US847279

申请日：1992-03-10

申请人： Tatsuya Tamaoki ,  Isami Takahashi ,  Katsuhiko Ando ,  Mayumi Yoshida ,  Toshiaki Iwazaki

发明人： Tatsuya Tamaoki ,  Isami Takahashi ,  Katsuhiko Ando ,  Mayumi Yoshida ,  Toshiaki Iwazaki

IPC分类号： C07J73/00

CPC分类号： C07J73/005

摘要： Disclosed is UCA1064-B, a compound represented by formula (I): ##STR1## and having an antibacterial, antifungal and anti-tumor activity. UCA1064-B is produced by culturing a microorganism belonging to the genus Wallemia.

公开(公告)号：US5066817A

公开(公告)日：1991-11-19

申请号：US516304

申请日：1990-04-30

申请人： Hirofumi Nakano ,  Mitsunobu Hara ,  Tsuyoshi Mokudai ,  Isao Kawamoto ,  Mayumi Yoshida ,  Eiji Kobayashi

发明人： Hirofumi Nakano ,  Mitsunobu Hara ,  Tsuyoshi Mokudai ,  Isao Kawamoto ,  Mayumi Yoshida ,  Eiji Kobayashi

IPC分类号： C07D407/04 ,  C12P17/06

CPC分类号： C07D407/04 ,  C12P17/06 ,  Y10S435/886

摘要： Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.

公开(公告)号：US07112571B2

公开(公告)日：2006-09-26

申请号：US10266609

申请日：2002-10-09

申请人： Katsuhiro Osajima ,  Eiji Seki ,  Mayumi Yoshida

发明人： Katsuhiro Osajima ,  Eiji Seki ,  Mayumi Yoshida

IPC分类号： A61K38/05

CPC分类号： A23J1/04 ,  A23L2/66 ,  A23L33/18 ,  A61K38/00 ,  C07K14/461

摘要： Peptide which is obtained by treating fish meat such as sardine with an alkaline protease is adsorbed with a peptide-adsorbing resin (such as ODS resin) and eluted with 10 aqueous ethanol to obtain a peptide (Y-2 fraction). The resulting novel peptide has an excellent hypotensive action and can be used as a nutrient and a specific health food and, in addition, it can be advantageously used as a hypotensive agent.

摘要翻译： 通过用碱性蛋白酶处理鱼肉如沙丁鱼获得的肽被肽吸附树脂（例如ODS树脂）吸附并用10％乙醇水溶液洗脱，得到肽（Y-2级分）。 所得的新型肽具有优异的降血压作用，可用作营养物质和特定保健食品，另外还可有利地用作降血压剂。

公开(公告)号：US6064470A

公开(公告)日：2000-05-16

申请号：US537352

申请日：1995-10-02

申请人： Kenji Karashima ,  Hisashi Fuzisaki ,  Mayumi Yoshida

发明人： Kenji Karashima ,  Hisashi Fuzisaki ,  Mayumi Yoshida

IPC分类号： G03G15/00 ,  G03G15/16

CPC分类号： G03G15/602 ,  G03G15/168 ,  G03G2215/1614 ,  G03G2215/1652

摘要： A contact type image transferring device and method incorporated in an image forming apparatus for cleaning a residual toner on a transfer roller. The transfer roller is in contact with a photoconductive drum at a first force and forms nip between the roller and the drum. A sheet of paper passes through the nip and a toner image on the drum is transferred to the sheet of paper. When the sheet of paper is not at the nip, the transfer roller is moved such that the force of the roller against the drum is a second force which is different from the first force. A cleaning bias voltage is applied to the roller and toner on the roller is transferred to the drum.

摘要翻译： 一种结合在用于清洁转印辊上的残留调色剂的图像形成装置中的接触型图像转印装置和方法。 转印辊以第一力与感光鼓接触并在辊和滚筒之间形成辊隙。 一张纸通过辊隙，鼓上的调色剂图像被转印到纸张上。 当纸张不在辊隙处时，转印辊被移动，使得辊抵靠鼓的力是与第一力不同的第二力。 将清洁偏压施加到辊上，并将辊上的调色剂转印到滚筒上。

公开(公告)号：US5887224A

公开(公告)日：1999-03-23

申请号：US862695

申请日：1997-05-23

申请人： Haruji Mizuishi ,  Masaru Tanaka ,  Shigeru Watanabe ,  Kenzo Tatsumi ,  Toshitaka Yamaguchi ,  Takeo Suda ,  Hiroshi Yoshinaga ,  Ken Amemiya ,  Mayumi Yoshida

发明人： Haruji Mizuishi ,  Masaru Tanaka ,  Shigeru Watanabe ,  Kenzo Tatsumi ,  Toshitaka Yamaguchi ,  Takeo Suda ,  Hiroshi Yoshinaga ,  Ken Amemiya ,  Mayumi Yoshida

IPC分类号： G03G15/08 ,  G03G21/10

CPC分类号： G03G15/0822 ,  G03G21/105 ,  G03G2215/0822

摘要： There is provided an image forming device capable of preventing smudges on the background of an image due to excess toner replenishment caused by a failure in stirring developer and toner enough to charge the toner or scattering of replenished toner without being charged. A toner conveying member for conveying replenished toner from a toner replenishing portion through a toner replenishing port to a developer stirring and conveying member is constructed by a screw member unitarily formed with the developer stirring and conveying member. The screw member has a spiral conveying fin capable of conveying the replenished toner at relatively high speed. The replenished toner is delivered to a toner replenishing portion provided in the upstream of a developer receiving portion of the screw member.

摘要翻译： 提供了一种图像形成装置，其能够防止由于搅拌显影剂的故障引起的多余的调色剂补充以及足以使调色剂充电或补充调色剂的飞散而不被充电而导致的图像背景上的污迹。 通过与显影剂搅拌和传送部件一体地形成的螺钉部件构成用于将补充调色剂从调色剂补充部分通过调色剂补充口输送到显影剂搅拌和传送部件的调色剂传送部件。 螺杆构件具有螺旋输送翅片，能够以相对高的速度输送补充的调色剂。 补充的调色剂被输送到设置在螺杆构件的显影剂接收部分的上游的调色剂补充部分。

公开(公告)号：US5737680A

公开(公告)日：1998-04-07

申请号：US746985

申请日：1996-11-19

申请人： Hiromitsu Takagaki ,  Shinji Kato ,  Hisao Murayama ,  Shigeru Watanabe ,  Mayumi Yoshida ,  Shunji Kato

发明人： Hiromitsu Takagaki ,  Shinji Kato ,  Hisao Murayama ,  Shigeru Watanabe ,  Mayumi Yoshida ,  Shunji Kato

IPC分类号： G03G15/08 ,  G03G21/00 ,  G03G21/10

CPC分类号： G03G21/105 ,  G03G15/0877 ,  G03G15/0896

摘要： An image forming apparatus capable of collecting a toner remaining on an image carrier after image transfer and conveying the collected toner to a developing unit to reuse it. A toner supplement roller and a toner conveyor are so controlled as to maintain the supplement of a fresh toner from a hopper to the developing unit and the supplement of the collected toner from the toner conveyor to the developing unit in a ratio lying in a predetermined range.