An isolation manifold includes a manifold body, a process connection at a first end of the manifold body, a pressure transmitter connection at a second end of the manifold body, a passageway through the manifold body, an isolation valve, and a pressure limiting device. The process connection is for fluidly connecting the isolation manifold to a process vessel or conduit containing a process fluid. The pressure transmitter connection is for fluidly connecting the isolation manifold to a pressure transmitter. The passageway fluidly connects the process connection to the pressure transmitter connection. The isolation valve is operable to selectively block the passageway to isolate the process connection from the pressure transmitter connection. The pressure limiting device fluidly connects to the passageway between the isolation valve and the pressure transmitter connection. The manifold may preferably include a pressure snubber within the passageway to increase the flow impedance of the passageway.