A multi-power domain operational amplifier includes an input stage circuit, a power domain transforming circuit and an active load. The input stage circuit is configured to transform a set of input voltages into a set of input currents in a first power domain. The power domain transforming circuit is configured to transform the set of input currents into a set of output currents in a second power domain. The active load is configured to generate an output voltage according to the set of output currents. A common mode range of the output voltage is shifted as compared with a common mode range of the set of input voltages.