发明授权
- 专利标题： Polynucleotides allowing the expression and secretion of recombinant pseudo-virus containing foreign epitopes, their production, and use
- 专利标题（中）： 允许含有外源表位的重组假病毒的表达和分泌的多核苷酸，其生产和用途
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申请号： US12678046申请日： 2008-09-12
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公开(公告)号： US09096868B2公开(公告)日： 2015-08-04
- 发明人: Qiang Deng , Marie-Louise Michel
- 申请人： Qiang Deng , Marie-Louise Michel
- 申请人地址： FR Paris FR Paris
- 专利权人： INSTITUT PASTEUR,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人： INSTITUT PASTEUR,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- 当前专利权人地址： FR Paris FR Paris
- 代理机构： Law Office of Salvatore Arrigo and Scott Lee, LLP
- 国际申请： PCT/EP2008/062208 WO 20080912
- 国际公布： WO2009/034182 WO 20090319
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C07K14/005 ; A61K39/00
摘要：
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.
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