Invention Grant
- Patent Title: Orthogonal translation components for the in vivo incorporation of unnatural amino acids
- Patent Title (中): 用于体内引入非天然氨基酸的正交翻译组分
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Application No.: US13492296Application Date: 2012-06-08
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Publication No.: US09102932B2Publication Date: 2015-08-11
- Inventor: Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
- Applicant: Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group, P.C.
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N9/00 ; C12P21/02 ; C12N15/10 ; C12P21/00
Abstract:
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Public/Granted literature
- US20130244245A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids Public/Granted day:2013-09-19
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