摘要:
The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.
摘要:
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要:
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
摘要:
A PCB includes a number of insulation layers, a number of circuit layers, a signal-interfering component, and a signal-sensitive component. The circuit layers and the insulation layers are stacked alternately. The circuit layers include at least two first circuit layers, a second circuit layer, and a ground layer. The ground layer has a first side and a second side facing away the first side. The first circuit layers are positioned near the first side and include an outmost first circuit layer and at least one inner first circuit layer positioned between the outmost first circuit layer and the ground layer. The second circuit layer is positioned near the second side. The signal-interfering component is positioned on the outmost first circuit layer. The signal-sensitive component is positioned on the second circuit layer. Each inner first circuit layer defines a copper-remove area corresponding to an orthogonal projection of the signal-interfering component thereon.
摘要:
An apparatus and method for examining fiber tension, fiber stress, sarcomere length, etc. in muscle fibers and tension and stress in ligament or tendon tissues as well as brain or nerve fibers by applying a lifting force to lift the fiber or tissue a lifting distance, measuring the lifting force and distance and calculating the axial tension on the fiber bundle or tissue. The apparatus and method also make it possible to illuminate and view the fiber bundle or tissue to examine and characterize visually observable properties.
摘要:
The invention is directed to droplet actuator devices and assay methods. The method may include, among other things, a method of conducting enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil, the method including incubating a droplet in oil, the droplet preferably comprising an umbelliferone substrate, a sample, and a cyclodextrin compound. The methods may further include a method of substantially eliminating cross-contamination between droplets in enzymatic containing substrate-based bioassays. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the inclusion complex may be formed using cyclodextrins. In yet another embodiment, the invention may provide a method of enhancing hydrolysis of enzymatic substrates. The methods may further include a method of forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the substrate may be a 4-MU- or HMU containing substrate. The inclusion complex may be formed using cyclodextrin.
摘要:
A method of preparing a universal base composition disclosed which consists of milling a pigment in a resin that is soluble in both water and organic solvent and wherein the resin contains both hydrophobic and hydrophilic monomers such that the total weight of the hydrophobic and hydrophilic monomers is at least about 20% of the total weight of the resin and the weight ratio of hydrophobic monomers to hydrophilic monomers is from about 1/5 to about 5.
摘要:
A method of clock transmission between networks and an apparatus of clock transmission are disclosed, in which a second group of information corresponding to a clock transferred by a first network equipment based on a first protocol, and the second group of information corresponding to a clock transferred by a second network equipment based on a second protocol are acquired, and a source selection is performed in a united way by adopting a source selection manner based on the second protocol according to the second group of information. Therefore, the equipment in different types of networks can conveniently select a clock with a higher class from clocks transferred based on different protocols, so as to realize a normalization management on the clocks transferred based on different protocols.
摘要:
A quasi-axial optical imagery projection system is disclosed in this paper. The system includes optical imagery sets; each may be lenses, mirrors, or a combination of both. The system also has a light source close to an imager, which may be a planar mask with a pattern, a LCD imager, or other suitable imagers. The system also has a display screen. Both the imager and the display screen are set at acute angles with respect to an optical axis so that what is projected on the display screen is a magnified image of the imager by a magnification factor that has a transverse component and a longitudinal component. This quasi-axial projection system may be made thinner than other rear projection system of comparable screen size.
摘要:
A method of fabricating a semiconductor device is disclosed. The method includes defining an electrode on a semiconductor substrate; forming a spacer on at least one sidewall of the electrode; performing a process operation on the semiconductor substrate using the spacer as a mask and forming a material layer on the top or the surface of the semiconductor substrate and the electrode; and removing the spacer by steps of performing a wet etching process at a temperature in a range of 100° C. to 150° C. to etch the spacer using an acid solution containing phosphoric acid as an etchant. With respect to another aspect, a method of removing a spacer is also disclosed. The method includes performing a wet etching process at a temperature in a range of 100° C. to 150° C. to etch the spacer using an acid solution containing phosphoric acid as an etchant.