Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
- Patent Title (中): 选择性糖苷酶抑制剂及其用途
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Application No.: US13697179Application Date: 2011-05-10
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Publication No.: US09120781B2Publication Date: 2015-09-01
- Inventor: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
- Applicant: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
- Applicant Address: CA Burnaby US NJ Rahway CA Burnaby
- Assignee: Simon Fraser University,Merck Sharp & Dohme Corp.,Alectos Therapeutics Inc.
- Current Assignee: Simon Fraser University,Merck Sharp & Dohme Corp.,Alectos Therapeutics Inc.
- Current Assignee Address: CA Burnaby US NJ Rahway CA Burnaby
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2011/000548 WO 20110510
- International Announcement: WO2011/140640 WO 20111117
- Main IPC: C07D263/56
- IPC: C07D263/56 ; C07D263/58 ; C07D277/82 ; C07D413/04 ; C07D417/04 ; C07D277/64 ; C07D263/52 ; C07D277/60
Abstract:
The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20130131044A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2013-05-23
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