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公开(公告)号：US09409924B2
公开(公告)日：2016-08-09
申请号：US14129177
申请日：2012-06-27
Applicant: Tong-Shuang Li , Ernest McEachern , David Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold Selnick
Inventor： Tong-Shuang Li , Ernest McEachern , David Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold Selnick
IPC: C07D513/04 , C07H9/06 , C07H13/04 , C07H13/12 , C07H15/18 , C12Q1/34 , C12Q1/48 , C12Q1/37 , G01N33/50
CPC classification number: C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
Abstract: The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号：US09120781B2
公开(公告)日：2015-09-01
申请号：US13697179
申请日：2011-05-10
Applicant: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
Inventor： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
IPC: C07D263/56 , C07D263/58 , C07D277/82 , C07D413/04 , C07D417/04 , C07D277/64 , C07D263/52 , C07D277/60
CPC classification number: C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
Abstract: The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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公开(公告)号：US08334310B2
公开(公告)日：2012-12-18
申请号：US12438882
申请日：2007-08-31
Applicant: David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
Inventor： David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
IPC: A61K31/429 , C07D513/04
CPC classification number: G01N33/6803 , C07D513/04 , C07D513/14 , C07F9/6561 , C07H9/06
Abstract: The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc
Abstract translation: 本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物或药物前体药物的药物组合物的式（I）化合物。本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达有关的疾病和病症的方法， O-GlcNAc的积累或不足
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公开(公告)号：US20050277670A1
公开(公告)日：2005-12-15
申请号：US11012002
申请日：2004-12-13
Applicant: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
Inventor： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC classification number: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
Abstract: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US08962664B2
公开(公告)日：2015-02-24
申请号：US13591927
申请日：2012-08-22
Applicant: David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
Inventor： David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
IPC: A61K31/429 , C07D513/04 , G01N33/68 , C07D513/14 , C07F9/6561 , C07H9/06
CPC classification number: G01N33/6803 , C07D513/04 , C07D513/14 , C07F9/6561 , C07H9/06
Abstract: The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶，化合物前药和包括化合物的化合物或前药的药物组合物的式（I）化合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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Patent Agency Ranking
公开(公告)号：US20130131044A1
公开(公告)日：2013-05-23
申请号：US13697179
申请日：2011-05-10
Applicant: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
Inventor： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
IPC: C07D417/04 , C07D277/60 , C07D413/04 , C07D263/52
CPC classification number: C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
Abstract: The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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公开(公告)号：US07491735B2
公开(公告)日：2009-02-17
申请号：US11012002
申请日：2004-12-13
Applicant: Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
Inventor： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
IPC: A61K31/4468
CPC classification number: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
Abstract: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US20070066624A1
公开(公告)日：2007-03-22
申请号：US11505669
申请日：2006-08-16
Applicant: Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
Inventor： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
IPC: A61K31/496 , A61K31/454 , C07D403/14 , C07D403/04
CPC classification number: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/08
Abstract: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
Abstract translation: 本发明涉及趋化因子受体结合化合物，药物组合物及其用途。 更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR4或CCR5的调节剂。 一方面，这些化合物表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。
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公开(公告)号：US09199949B2
公开(公告)日：2015-12-01
申请号：US14129163
申请日：2012-06-27
Applicant: Tong-Shuang Li , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Harold G. Selnick
Inventor： Tong-Shuang Li , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Harold G. Selnick
IPC: C07D263/58 , C07D413/04 , C07D417/04 , C07D277/60 , A61K31/423 , A61K31/428 , C07D277/82 , C12Q1/37 , C07D263/52
CPC classification number: C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
Abstract: The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号：US20150045346A1
公开(公告)日：2015-02-12
申请号：US14129163
申请日：2012-06-27
Applicant: Tong-Shuang Li , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Harold G. Selnick
Inventor： Tong-Shuang Li , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Harold G. Selnick
IPC: C07D277/60 , C07D263/52
CPC classification number: C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
Abstract: The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物的化合物或前药的药物组合物的化合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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